In order to control exsanguination from traumatized liver or ruptured hepatoma or to palliate tumor growth, interruption of arterial flow to the lil·or is well documented. Occlusion of the portal vein mar play a role for palliation of the growth of primary hepatoma. And iatrogenic hazard to hepatic artery and/or portal vein may occur during surgical procedure on the upper abdomen.
The interruption either of arterial or portal flow to the liver should be fellowed by some adverse effect of liver function. Although many articles have been published for the histopathologic changes and deterioration of liver function after interruption of hepatic artery or portal vein, few comprehensive study of liver function change has been reported as yet.
Author carried out an experimental study of alternation of hepatocyte activity after ligation of the proper hepatic artery and stenosing the portal vein of rabbits.
Sixty adult healthy rabbits irrespective of sex weighing about 2kg were subjected to this study.
The subject of liver function were studied after ligation of the hepatic artery and stenosis of the portal vein in normal rabbits on serum glutamic oxaloacetic transaminase, serum pyruvic transaminase, serum alkaline phosphatase activity, blood urea nitrogen, glucose, total bilirubin, albumin, and globulin.
The result were as follows:
1. The values of the serum glutamic oxaloacetic transaminase(SGOT), serum glutamic pyruvic transaminase(SGPT), and serum alkaline phosphatase activity(AP) has showed gradual rise from 5 to 30 days after procedure to the level of about twice of normal level in the group of the arterial ligation.
On the other hand, in the values of SGOT, SGPT, and AP rose abruptly and steeply up in the early days, 5 or 10 days after procedure hut thereafter those levels decreased gradually as the days go by and returned to normal level in 30 days. And these alterations were statistically significant changes (P<0.01) each other.
2. The values of serum total bilirubin(TB) and blood urea nitrogen(BUN) were observed no significant changes statistically(P>0.05).
3. The values of glucose of both experimental groups decreased steeply to the level of about two third on the 5 days after operation, and thereafter the group of proper hepatic artery ligation has continued to decrease as days go by.
Meanwhile the values of the group of the portal vein stenosis has decreased as days go by and returned to almost the same level of the control group. And these were statistically significant changes, P<0.01 respectively.
4. The values of serum albumin decreased slightly in early days after the both operation and continued to decrease from begining to 30 days after proper hepatic artery ligation at around the level of about a half values of control group.
On the other hand it has tendency to increase and returned to normal in the group of portal vein stenosis. And these had statistically significant changes, P<0.01 respectively.
5. The serum globulin level of both experimental groups threw the mirror image on the side of above the control level to the serum albumin level which is located on the other side, below, of the control level(Fig 7 & 8).
6. It seems to suggest that almost all of the values of portal stenosis group which was aggravated in early days, has had a tendency to the values of control group as days go by, means that stenosis of portal system to the liver may enhance the development of collateral channels.
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